Cyberpunk 2077: The Ultimate Psycho Killer Quest Guide & Rewards
Master the 'Psycho Killer' questline in Cyberpunk 2077, where you must incapacitate victims of cyberpsychosis for Regina Jones's experimental cure.
Night City is a brutal place, and sometimes its inhabitants can't handle the chrome. In the sprawling RPG Cyberpunk 2077, one of the most persistent and rewarding side job chains is the 'Psycho Killer' questline, given by the fixer Regina Jones. Think you're just a mercenary taking out threats? Think again. This mission is about mercy, not murder. Your goal isn't to kill these victims of cyberpsychosis, but to incapacitate them so Regina's team can provide an experimental cure. Ready to hunt down Night City's most dangerous and disturbed souls?
🎯 How To Start The Hunt

Regina will call you early in Act 1, but the quest truly unfolds over the entire game. A few gigs pop up after 'The Rescue', but the majority become available in Act 2. Pro tip? Complete the 'Transmission' main job to unlock them all. And remember, after each fight, use your scanner! Finding relevant shards is crucial to understanding what drove these people over the edge and officially closing each case.
⚔️ Act 1 Cyberpsycho Encounters (Watson District)
The first batch of unstable souls are found in Watson. Don't get cocky—these early fights can be surprisingly tough!
- Demons of War: Your likely first encounter. Find Matt Liaw under a highway in north Kabuki, already battling NCPD. 🚨 Warning: His shotgun will delete your health bar in seconds. Be smart, use cover!

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Six Feet Under: Follow the train tracks in Northside to find Lely Hein. He also has a shotgun, but this is a perfect opportunity for a stealth takedown. Why fight fair?
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Lt. Mower: Under a highway on Kabuki's west side, surrounded by Militech vehicles. This lieutenant uses stealth camo and Gorilla Arms. Can you spot her before she punches your lights out?
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Where The Bodies Hit The Floor: In a southwest Northside alley, Elias Carter is a blur of motion. He dodges bullets! Maybe it's time to get up close and personal with a melee weapon?
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Ticket To The Major Leagues: West of Little China, near the bridge. Alec Johnson sports devastating Gorilla Arms. The strategy here? Keep your distance! Ranged weapons are your best friend.
🔥 Act 2 Cyberpsycho Encounters (City-Wide)
As you progress, the gigs spread across Night City and the Badlands. The challenges get more creative and deadly.
| Quest Name | Location | Key Threat & Strategy |
|---|---|---|
| Letter of the Law | Southwest Wellsprings, Heywood | Gaston Phillips laced the area with landmines. Sneak and disable them first, then watch out for his SMG. |
| Seaside Cafe | South Wellsprings, Heywood | Dao Hyunh is lightning fast. Ambush her with your heaviest weapon. Don't forget the two required shards nearby! |
| Discount Doc | South Rancho Colorado, Santo Domingo | Chase Coley is in a mecha suit. Patience! Chip away his health while constantly moving to avoid his massive gun. |
| Under The Bridge | West Arroyo, Santo Domingo | Tamara Cosby is a netrunner controlling two turrets. Rush her to break her concentration before she sets them up. |
| Smoke on the Water | Northern pier, Coastview, Pacifica | Diego Ramirez waits with a shotgun. Check the van under the pier first for crucial story context. |
| Lex Talionis | (Requires 'Transmission' Quest) Eastern pier, Coastview, Pacifica | Ben Debaillon sends drones and androids as welcome gifts. Clear them, and he's easy with just a pistol. |
| Bloody Ritual | Western Northside, Watson | Investigate a creepy scene to summon Zaria Hughes. She uses Quickhacks and Mantis Blades. Come heavily armed or you might fail the non-lethal objective. |

🏜️ The Badlands Bounties
Venturing into the desert? Two of the toughest psychos await.
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The Wasteland: Deep in the Badlands, east of Dex's dumpster. Follow a blood trail from a car crash to find Euralio Alma in a mecha suit. Every suit has a weak spot—find the one on its back for a quicker victory.
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Second Chances: Further east in the Badlands. Another car, another blood trail leading through carnage to a wind turbine. Zion Wylde is a sniper on a high platform. The play? Sneak or use Optical Camo. And for heaven's sake, watch out for his landmines!
🏙️ City Center Showdowns
Back in the urban jungle, the final psychos test your skills.
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House on a Hill: Inside a fenced Badlands farm near Dakota Smith. It's not just the psycho—drones and turrets guard the area. Hacking skills recommended! Russell Greene in the garage has a devastating shotgun. Max that armor!
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On Deaf Ears: Cedric Muller is causing chaos in a Downtown City Center parking garage. He's fast and has a powerful shotgun. The classic strategy applies: keep your distance and pepper him with fire.
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Phantom of Night City: The grand finale? Find Norio Akuhara in an alley west of Corpo Plaza. He starts with a sword, but when hurt, he retreats to full health for a second phase, bringing Tyger Claws reinforcements. A true two-part boss fight!
💰 The Ultimate Reward

After subduing all 17 cyberpsychos, Regina will call for a meet. Your dedication to non-lethal justice pays off handsomely:
💰 25,000 Eurodollars
🛡️ Trauma Team Armor-weave Tactical Vest
🛡️ Decadencia Verde Tactical Armor-weave Pants
Completing this questline isn't just about loot; it's a deep dive into the tragic human cost of Night City's chrome addiction. Each shard tells a story of a life pushed too far. So, are you ready to be a hero, a hunter, and a detective all in one? The psychos of Night City are waiting.